Based on research and analysis of the Tibetan spelling grammar, a computer Tibetan fast input keyboard layout is described by formalization, and some rules and method of Tibetan keyboard layout are derived. According to the Tibetan character’s frequency statistics, the rules of Tibetan keyboard layout, Dvorak keyboard keystroke convenient index, in order to facilitate memor and consider the similarity in pronunciation of English and Tibetan alphabet, a non-repeated code Tibetan keyboard layout is designed. Finally, it proves that the design of the keyboard layout proposed above is more scientific than the other input methods through the average number of keystrokes.